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What Are Over-the-Counter Medications?
Over-the-counter medications are drugs you can buy without a prescription. They include pain relievers, cold and flu treatments, antacids, allergy medicine and many more. While many are safe during pregnancy, some can interfere with your baby’s development, especially in the first trimester.
Approved OTC Medications for Pregnancy: What’s Considered Safe?
Here’s a breakdown of common symptoms and the OTC medications you can typically take while pregnant. Remember, it’s always best to check with your healthcare provider before using any medication, even the ones labelled safe.
For Headaches and Mild Pain
If you’re struggling with headaches, backaches, or muscle pain:
- Acetaminophen (Tylenol) is the go-to pain reliever that most doctors approve during all trimesters.
- Avoid NSAIDs like ibuprofen or aspirin unless specifically directed by your doctor.
This is one of the safest OTC headache medicines while pregnant, but dosage matters—stick to the lowest effective dose for the shortest time.
For Cold, Flu, and Congestion
- Pregnancy-safe OTC cold medicine options include:
- Acetaminophen for fever or body aches
- Diphenhydramine (Benadryl) for sneezing or sleep support
- Dextromethorphan for dry cough
- Saline nasal sprays for congestion
- For OTC decongestants safe during pregnancy, avoid oral decongestants like pseudoephedrine in the first trimester. However, nasal sprays like oxymetazoline may be used short-term after consulting your doctor.
- If you’re specifically looking for OTC cold and flu medicine safe for pregnancy, always read the labels and avoid multi-symptom drugs that include alcohol, caffeine, or NSAIDs.
For Sinus Pressure and Allergies
- OTC sinus medicine safe for pregnancy includes:
- Saline rinses
- Acetaminophen for sinus pressure
- Some antihistamines like loratadine (Claritin) or cetirizine (Zyrtec)
These are part of the approved OTC medications for pregnancy when taken as directed.
For Heartburn and Indigestion
Heartburn can be relentless, especially as your belly grows. There are pregnancy-friendly medications:
- Maalox is safe for pregnant women and is commonly recommended for acid relief.
- Mylanta, safe for pregnancy, is another effective option for quick indigestion relief.
- Tums and Rolaids (calcium carbonate) are also considered safe OTC heartburn medications during pregnancy.
Just remember not to overuse antacids with high sodium content.
For Nausea and Morning Sickness
- Vitamin B6 and doxylamine (found in Unisom SleepTabs) can help with nausea.
- Pregnancy-safe over-the-counter medications for nausea also include ginger supplements and sea bands for motion sickness.
If vomiting becomes severe, talk to your doctor; there are prescription options available, too.
For Constipation and Hemorrhoids
Digestion can slow down during pregnancy, but relief is within reach.
- Colace (docusate sodium) is a gentle stool softener often recommended.
- Fibre supplements and psyllium husk (Metamucil) are also good OTC options.
- For haemorrhoids, witch hazel pads and Preparation H are typically safe.
For Sleep Troubles
Insomnia is common during pregnancy, especially in the third trimester.
- Diphenhydramine (Benadryl) and doxylamine may help you sleep, but they shouldn’t be used long-term.
- Always avoid sleep aids with alcohol or melatonin unless your doctor approves.
Important Safety Tips Before Taking OTC During Pregnancy
- Always check the label for multiple active ingredients. Multi-symptom meds can contain unsafe drugs.
- Avoid high-dose or long-term use of any medication.
- Talk to your OB-GYN doctor if you’re unsure about anything—even if it’s labelled “natural” or “herbal.”

Your Takeaway
While this list of OTC medications safe during pregnancy covers many common symptoms, it’s still essential to consult your healthcare provider before starting any medication. Every pregnancy is different, and what’s safe for one person might not be ideal for another.
Being cautious doesn’t mean you have to suffer through every headache, sneeze, or upset stomach. With a little guidance, you can find relief that’s both effective and baby-safe.
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